Resveratrol 98% / 1.2 grams

This Resveratrol comes from the natural polygonum cuspidatum plant root. The plant root is cleaned and made into powder. The powder then goes through an extraction process using alcohol and water. The extract from the process contains concentrated phytonutrients. This polygonum powder extract is then tested specifically for Trans-Resveratrol content to assure us of the amount of Trans-Resveratrol it contains. The powder is verified a second time using HPLC scientific lab equipment at the American Analytical Chemistry Labs in Illinois, for safety and purity.

Properties:

* very effective anti-oxidant which helps to fight free radical skin damage
* packed with vitamins and minerals
* skin food in the form of phytonutrients [proanthocynidin]
* topically fights carcinogens
* inhibitor of enzyme oxidative activity

Applications: crafting own skin care/creams and lotions

Facts:

Resveratrol … is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-activated receptor coactivator-1a (PGC-1a) and FOXO activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. That was a mouthful!!

You may have heard … that the incidence of heart disease in France is far lower than in the U.S. Scientists spent a long time trying to figure out how that could possibly be when the traditional French diet – lots of cheese, bread, sauces, wine with every meal - includes pretty much everything we’re advised not to eat. After much research, they think they’ve found the secret - an excellent anti-aging ingredient you might want to add to your skin care routine.

What is the magic ingredient? It’s called resveratrol, is found in many red wines, and is an antibiotic produced by plants when under attack by bacteria, fungi and other substances that can cause disease or illness. Although the formal research has been conducted primarily in test tubes and on animals, resveratrol has reportedly been effective in fighting viruses, inflammation, cancer and neurological diseases. It is also being touted for its anti-aging effects.

While antibiotics are not new in the skin care field for some skin diseases, it’s unusual to think that an antibiotic can also be effective when it comes to aging. However, many scientists now believe that a host of degenerative diseases are actually caused by bacteria and inflammation. That certainly is true of some skin conditions, which is one of the reasons for the popularity of antibacterial skin care products.

PubMed.gov

Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin.
School of Medicine, Fu Jen Catholic University, Taipei County 242, Taiwan.

Resveratrol, the main active polyphenol in red wine, has been demonstrated to show benefits against skin disorders. The bioavailability of orally administered resveratrol is insufficient to permit high enough drug concentrations for systemic therapy. In this study, we examined the feasibility of the topical/transdermal delivery of resveratrol. The effects of vehicles on the in vitro permeation and skin deposition from saturated solutions such as aqueous buffers and soybean oil were investigated. The general trend for the delivery from solutions was: pH 6 buffer=pH 8 buffer>10% glycerol formal in pH 6 buffer>pH 9.9 buffer>pH 10.8 buffer>soybean oil. A linear relationship was established between the permeability coefficient (K(p)) and drug accumulation in the skin reservoir. Viable epidermis/dermis served as the predominant barrier for non-ionic resveratrol permeation. On the other hand, both the stratum corneum (SC) and viable skin acted as barriers to anionic resveratrol. Several prototype hydrogel systems were also studied as resveratrol vehicles. The viscosity but not the polarity of the hydrogels controlled resveratrol permeation/deposition. Piceatannol, a derivative of resveratrol with high pharmacological activity, showed 11.6-fold lower skin permeation compared to resveratrol. The safety profiles of resveratrol suggested that the hydrogel caused no SC disruption or skin erythema. It was concluded that delivery via a skin route may be a potent way to achieve the therapeutic effects of resveratrol. This is the first report to establish the permeation profiles for topically applied resveratrol.